What Are The Causes Of Pancreatic Cancer?

March 10, 2023
Precede Foundation

Pancreatic Cancer is one of the deadliest common forms of cancer. Anyone can get pancreatic cancer. It affects women and men equally, across all races and ethnicities around the globe. African Americans and people of Ashkenazi Jewish descent have elevated risk for developing the disease. 

Pancreatic cancer is a disease caused by damage or mutations to the DNA. It’s not clear what causes pancreatic cancer. However, research has identified some risk factors that may lead to these mutations and the development of pancreatic cancer.

These risk factors are known to increase your chances of developing pancreatic cancer:

  • Age
  • Pancreatitis
  • Obesity
  • Diabetes
  • Smoking
  • Family History

Understanding Your Pancreas

Why is the pancreas a vital organ? The pancreas is a gland that is part of the digestive system. It produces insulin and other important enzymes and hormones that help break down foods into smaller molecules that can be absorbed in the intestines. 

It plays an important role in healthy digestion and is vital for the absorption of vitamins and nutrients which support the liver, kidneys, nervous system and cardiovascular system.

Unfortunately, the pancreas is difficult to reach and its complexities make it susceptible to various disorders including pancreatic cancer. Here are some ways to keep your pancreas healthy:

  • Maintain a healthy weight
  • Eat a low-fat diet
  • Watch your alcohol intake
  • Avoid smoking

Inherited Gene Mutations

Is pancreatic cancer hereditary? An individual is more at risk for pancreatic cancer if they meet one or more of the following conditions:

  • At least two first-degree relatives (Parent, sibling, or child) have had pancreatic cancer.
  • There are three or more relatives with pancreatic cancer on the same side of the family.
  • There’s a known family cancer syndrome plus at least one family member with pancreatic cancer.

Do you have a family history of pancreatic cancer? New research links specific genes and mutations to an increased likelihood of developing pancreatic cancer. However, only some of these genes are hereditary. According to the American Cancer Society: “Up to 10% of pancreatic cancers develop as a result of inherited genes.”

Certain genetic factors may increase the risk for pancreatic cancer, including:

  • BRCA2 & BRCA1 Mutation – Both mutations increase the risk of breast, ovarian cancer, and pancreatic cancer.
  • PALB2 Mutation – Women with a PALB2 mutation are at increased risk for several types of cancer including pancreatic.
  • HNPCC (Hereditary Non Polyposic Colorectal Cancer) Lynch Syndrome – Lynch syndrome is the most common hereditary cancer. People who have Lynch syndrome may have a nine fold increase in the risk for pancreatic cancer.
  • Peutz-Jeghers Syndrome (PJS) – It is a disorder in which polyps grow in the digestive tract. This condition can be developed in the small and large intestine, it can cause bleeding and blockages.
  • Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM) – It is characterized by multiple moles and a family history of melanoma.

Acquired Gene Mutations

An acquired gene mutation is not inherited from a parent. They occur and develop during a person’s life. It can’t be passed to a person’s children because this type of mutation does not affect sperm or egg cells.

These acquired gene mutations sometimes result from environmental factors, such as smoking or exposure to certain chemicals. Smoking is one of the major pancreatic cancer risk factors.

People who smoke are two (2) times more likely to develop pancreatic cancer compared to those who have never smoked before. About  20-35% of pancreatic cancers are caused by cigarette smoking. This means that quitting today can have a significant impact on your future health.

How You Can Help Early Detection Research

Without early diagnosis and intervention, most patients are diagnosed when their cancer has progressed to a late stage, leaving patients and their loved ones feeling hopeless. We cannot allow this devastation to continue, and it is vital that we find a solution to the gap in early diagnosis for pancreatic cancer.

Together, there is hope. TrovaNOW proceeds go towards collaborative research to detect pancreatic cancers earlier, saving thousands of lives from the world’s deadliest cancer.

If you have any questions or If you want more information about how to donate, just email us at trovanow@gmail.com

Knowing When To Ask For Help

There’s strength in recognizing when you need additional support. If you’re feeling consistently overwhelmed, anxious, or depressed, it may be time to speak with a healthcare professional. Warning signs can include ongoing sleep trouble, loss of appetite, or emotional numbness.

Mental health care is an important part of cancer recovery. There are therapists, social workers, and cancer-specific counselors trained to support your unique needs. Don’t hesitate to seek them out.

Your medical team can help adjust medications or recommend physical therapy if your symptoms are impacting your daily life. Being honest about your struggles allows your care providers to offer better, more personalized support.

The path to recovery from pancreatic cancer is rarely straightforward. It’s a mix of triumphs and setbacks, strength and vulnerability. But through each high and low, healing is happening. Be gentle with yourself. Allow space for rest, reflection, and growth.

You don’t have to go through this journey alone. With the right support, emotional, physical, and practical, you can move forward, one step at a time. And remember, every day you show up for yourself is a victory.

At TrovaNOW, we’re focused on finding a cure for pancreatic cancer. Every test and discovery brings us closer to better treatments and saving lives. Join us and learn more at TrovaNOW.

Visual related to precede biosamples help to validate  immunovia's analytical validation of its next-generation pancreatic cancer test

PRECEDE Biosamples help to validate Immunovia’s analytical validation of its next-generation pancreatic cancer test

Immunovia completes analytical validation of its next-generation pancreatic cancer test

Visual related to 4 pain management strategies for pancreatic cancer patients

4 Pain Management Strategies For Pancreatic Cancer Patients

Pancreatic cancer is known for being one of the most challenging and painful types of cancer to endure. Pain is a common symptom experienced by many pancreatic cancer patients due to the tumor’s location, treatments, and its progression. Effectively managing pain is crucial for improving the quality of life and overall well-being of patients. This blog will explore various pain management strategies, both medical and non-medical that can help alleviate pain and provide relief.

Pain In Pancreatic Cancer

  • Causes Of Pain In Pancreatic Cancer

Pain in pancreatic cancer can arise from different causes. As the tumor grows, it can press against organs, nerves, or tissues, leading to intense pain, particularly in the abdomen and back. Nerve involvement, where the tumor presses on nearby nerves, can lead to neuropathic pain, a burning or stabbing sensation that can be particularly difficult to manage. Treatments like chemotherapy and radiation therapy often cause side effects that contribute to pain and discomfort.

Understanding the source of the pain is the first step in effective pain management. While most patients experience abdominal pain, many also deal with neuropathic pain due to the tumor pressing on the nerves, making it essential to adjust treatments to address the type and intensity of pain.

  • The Emotional Impact Of Pain

Pain does not just affect the body; it can have a deep emotional and psychological toll. Chronic pain can lead to feelings of frustration, anxiety, and depression. When managing pancreatic cancer pain, it is crucial to take a holistic approach, addressing both physical discomfort and emotional well-being. By incorporating emotional and psychological support into a pain management plan, patients can feel more confident and in control of their journey.

1 – Medical Pain Management Options

Medical treatments remain one of the most common and effective ways to manage cancer pain. The approach to medical pain management can be customized based on the patient’s needs and the nature of their pain.

  • Medications

    • Opioids

These are often prescribed for moderate to severe cancer-related pain. Drugs like morphine, oxycodone, and fentanyl are commonly used to provide relief. Opioids are effective but require careful monitoring due to the risk of dependency and side effects like constipation and drowsiness.

    • Non-Opioid Pain Relievers

Over-the-counter medications such as NSAIDs (ibuprofen) or acetaminophen can also help manage milder pain or be used in conjunction with opioids for added relief.

    • Adjuvant Medications

In some cases, medications typically used for other conditions, like antidepressants or anticonvulsants, can be helpful for managing neuropathic pain. These medications help by altering nerve signals and reducing the perception of pain.

  • Radiation Therapy

Radiation therapy can be used to shrink tumors that are pressing against nerves or organs, thereby reducing pain. While primarily a treatment to control cancer growth, radiation can also provide significant pain relief by reducing the tumor’s size and relieving pressure on surrounding tissues. This can be particularly beneficial for patients who cannot undergo surgery or who are in the advanced stages of the disease.

  • Nerve Blocks And Surgical Interventions

For some patients, more targeted interventions such as nerve blocks may be necessary. A celiac plexus block involves injecting alcohol or medication to block the nerves that carry pain signals from the pancreas. This technique can offer significant relief from abdominal pain. In certain cases, surgical interventions may be required to reduce tumor-related obstructions or nerve pressure that contribute to pain. These surgical options are usually considered when other pain relief methods are insufficient.

2 – Non-Medical Pain Management Approaches

In addition to medical treatments, many non-medical approaches can complement traditional pain management strategies, helping to reduce discomfort and improve the overall well-being of patients.

  • Physical Therapy And Exercise

Gentle physical activity can help alleviate certain types of pain. Physical therapy can improve mobility and strengthen muscles, reducing pressure on joints and muscles that may be causing pain. Exercise, even in small amounts, can help to release endorphins, the body’s natural painkillers, which help to relieve discomfort. A customized exercise program, supervised by a healthcare provider, can be a powerful tool in managing cancer-related pain.

  • Complementary Therapies

    • Acupuncture

This ancient practice involves inserting thin needles into specific points on the body to stimulate nerves and reduce pain. Many cancer patients find acupuncture to be helpful for managing pain and reducing inflammation.

    • Massage Therapy

Regular massage can relieve muscle tension and improve circulation, reducing overall pain and promoting relaxation.

    • Mind-Body Techniques

Relaxation techniques like meditation, yoga, and deep breathing exercises can help to calm the mind and body, reducing stress and anxiety, which can exacerbate pain. By focusing on mindfulness and controlled breathing, patients can improve their ability to cope with chronic pain.

  • Diet And Nutrition

A well-balanced diet is important for overall health and can contribute to pain management. Certain foods have anti-inflammatory properties and can help reduce discomfort. Patients should focus on eating foods rich in antioxidants, healthy fats (like omega-3 fatty acids), and lean proteins. Maintaining proper hydration is also essential, as dehydration can worsen symptoms of pain. Consulting with a nutritionist who specializes in oncology can help develop a meal plan that supports pain management and overall well-being.

3 – Psychological And Emotional Support

Managing pain isn’t just about physical treatments; addressing the emotional and mental challenges of pain is equally important. Psychological support can make a significant difference in a patient’s pain management journey.

  • Cognitive Behavioral Therapy (CBT)

CBT is a psychological treatment that helps patients reframe their thoughts about pain, reduce catastrophizing, and develop coping strategies. This therapy can be particularly useful for patients struggling with the emotional toll of chronic pain, as it helps them regain a sense of control over their condition.

  • Counseling And Support Groups

Individual counseling or therapy sessions can provide a safe space for patients to express their frustrations, fears, and anxieties related to their pain and illness. In addition, support groups offer a sense of community, allowing patients to share their experiences and learn from others facing similar challenges. Support groups can be especially helpful for emotional healing and providing a sense of belonging during a difficult time.

4 – Personalized Pain Management Plans

Effective pain management often requires a multidisciplinary team of healthcare providers, including oncologists, pain specialists, physical therapists, and mental health professionals. This team-based approach allows for a personalized pain management plan that addresses the unique needs of each patient.

Patients should also maintain open and honest communication with their healthcare providers about their pain levels, symptoms, and any changes they experience. Keeping a pain journal or regularly reporting pain levels can help healthcare professionals adjust pain management strategies as needed. It’s also important for patients to ask about potential side effects and alternatives if their current pain management plan is not effective.

 

Managing pain for pancreatic cancer patients involves more than just addressing physical discomfort, it’s about improving overall quality of life through medical, non-medical, and emotional strategies. When facing pancreatic cancer, fighting is the only option. Together, we can work toward making this diagnosis a thing of the past.

At TrovaNOW, our mission is to raise funding for collaborative research focused on early detection and prevention, with the aim of increasing the 5-year survival rate from 12% to 50% within the next 10 years. Visit TrovaNOW to donate and join us in supporting the fight against pancreatic cancer. Together, we can bring hope and work toward better outcomes for patients and their families.

 

Visual related to how to manage fatigue in pancreatic cancer recovery

How To Manage Fatigue In Pancreatic Cancer Recovery

Recovering from pancreatic cancer is a physically and emotionally demanding journey. While every patient’s experience is different, one of the most persistent challenges many face during and after treatment is fatigue. Fatigue is not the same as ordinary tiredness, it’s an overwhelming sense of exhaustion that doesn’t improve with rest and can significantly affect the quality of life. 

Pancreatic cancer treatments, including chemotherapy, radiation, and surgery, are rigorous on the body. Many patients feel drained as their bodies work to heal and recover. Emotional and psychosocial stress also contributes to this fatigue, often making it difficult to carry out daily activities. 

This blog provides practical strategies for managing fatigue during pancreatic cancer recovery, helping patients regain energy, and addressing the challenges of post-treatment fatigue. With the right approaches, it is possible to enhance quality of life and take meaningful steps toward recovery. 

Fatigue In Pancreatic Cancer Recovery

Fatigue is one of the most common side effects of pancreatic cancer treatments. It can be caused by the treatments themselves, such as chemotherapy, which targets not only cancer cells but also healthy cells, leaving the body depleted of energy. Surgery, which is often necessary in treating pancreatic cancer, puts a lot of stress on the body as it recovers after surgery. Radiation therapy can cause extreme tiredness as the body tries to heal the damage to both cancerous and surrounding tissues.

Patients also experience mental fatigue, which may manifest as difficulty concentrating or remembering details. This “brain fog” is a common side effect of treatments that affect the brain’s ability to function at its best.

The duration and severity of fatigue can change. For some, it may only last a few weeks after treatment, while for others, it can persist for months or even years. Understanding that fatigue is a natural part of recovery can help patients manage their expectations and approach treatment with patience.

1 – Importance Of Rest And Sleep

Adequate rest and quality sleep are essential for managing fatigue during recovery. Fatigue often feels never-ending, and the need to rest becomes important for recovery. Establishing healthy sleep habits is crucial. This includes sticking to a consistent sleep schedule, ensuring the bedroom environment is comfortable and free from distractions, and avoiding stimulants like caffeine before bed.

Resting during the day is also important. While extended naps might interfere with nighttime sleep, short naps of 20-30 minutes can help recharge your energy without making you feel groggy.

In addition to physical rest, mental rest is equally important. Taking breaks from mentally exhausting activities and engaging in relaxing activities, like reading or listening to soothing music, can help ease both mental and physical fatigue. Avoid overstimulation before bedtime, such as watching TV or using smartphones, as this can interfere with your ability to fall asleep. Creating a calm nighttime routine can signal your body that it’s time to wind down.

2 – Prioritizing Nutrition For Energy

Maintaining a balanced, nutrient-rich diet is important for fighting fatigue during pancreatic cancer recovery. Eating the right foods can provide the body with the energy it needs to heal and function optimally. A diet rich in fruits, vegetables, lean proteins, and whole grains offers essential nutrients to keep energy levels stable. 

Protein, in particular, is important for tissue repair and recovery. Including lean meats, fish, eggs, and plant-based proteins like beans and lentils in your meals can help speed up recovery while providing long-lasting energy. Carbohydrates, especially from whole grains, provide the fuel your body needs throughout the day.

Hydration is just as important. Even mild dehydration can worsen feelings of fatigue. Ensure you’re drinking plenty of water throughout the day, and consider consuming water-rich foods like cucumbers, melons, and leafy greens.

Instead of eating three large meals, opt for smaller, frequent meals to avoid energy crashes. This approach ensures your body has a constant supply of nutrients and can prevent the dips in energy that often occur after consuming large amounts of food at once. 

3 – Incorporating Light Physical Activity

Gentle physical activity can help reduce fatigue and boost energy levels during recovery. Exercise increases circulation, improves muscle strength, and releases endorphins, which can elevate mood and overall energy. 

Start with light activities such as walking, stretching, or yoga. Short walks around your home or garden can improve circulation without putting too much strain on the body. Over time, as your strength improves, you can gradually increase the duration and intensity of your activity.

It’s important not to push yourself too hard. Overexertion can lead to increased fatigue rather than relief. Instead, listen to your body and take breaks when needed. Working with a healthcare provider or physical therapist can help you develop a personalized exercise plan suited to your recovery stage. They can recommend exercises that build stamina without risking injury or exacerbating fatigue.

By incorporating gentle movements into your daily routine, you can slowly rebuild your strength, improve your mood, and manage your fatigue more effectively, helping you feel more in control of your recovery process. 

4 – Managing Mental And Emotional Health

Fatigue during recovery is not just physical, mental and emotional fatigue are also common. Stress, anxiety, and depression can worsen feelings of exhaustion, making it essential to care for your mental health during this time. 

Mindfulness practices, such as meditation and deep breathing exercises, can help manage stress and provide a mental break from the demands of recovery. Setting aside just a few minutes a day to focus on breathing or practicing mindfulness can improve focus, reduce stress, and even boost your energy levels. 

Maintaining connections with loved ones is also important. Surrounding yourself with supportive family and friends can ease the emotional burden of recovery. Let them know how you’re feeling and allow them to help with tasks that may be too draining for you.

If emotional fatigue becomes overwhelming, consider seeking professional counseling. A therapist who specializes in cancer recovery can provide coping strategies to manage emotional stress. Support groups can also be beneficial, allowing you to connect with others who are experiencing similar challenges. The emotional support from these resources can help lighten the mental load and provide encouragement during recovery. 

5 – Setting Realistic Goals And Expectation

Recovery is a gradual process, and it’s important not to rush or overburden yourself. Instead of trying to tackle large tasks all at once, break them into smaller, more manageable steps. If a particular task seems overwhelming, spread it out over several days. This allows you to maintain productivity without overexerting yourself.

Celebrate small victories along the way. Even minor accomplishments, such as preparing a meal or going for a short walk can signify progress. Recognizing these achievements can help keep you motivated and remind you that you’re moving forward, even if the progress feels slow.

Understanding that fatigue is a natural part of the recovery process can also help ease frustration. Setting realistic timelines and listening to your body can help you find balance and avoid burnout, giving you more control over your energy levels. 

 

While fatigue may feel overwhelming, understanding that it’s a normal part of recovery can provide reassurance. With patience and a strategic approach, it’s possible to improve energy levels and regain control over your day-to-day life. Each small step forward, whether it’s achieving better sleep, eating a balanced meal, or incorporating light physical activity, brings you closer to feeling like yourself again.

Support pancreatic cancer early detection and prevention by donating to TrovaNow. Your contribution can make a significant difference in the fight against this disease. Visit their website for more information on how you can help.