New Emerging Methods Of Early Detection

December 20, 2023

Precede Foundation

Pancreatic cancer remains one of the most challenging cancers to detect early, resulting in a staggeringly low 12.5% five-year survival rate in the United States. The urgency to find innovative approaches and methods is more pressing than ever. Over 64,000 new cases are expected to be diagnosed in 2023 alone, making it the third deadliest cancer in the country.

Early detection is a critical factor in the battle against cancer, especially for diseases like pancreatic cancer, where delayed diagnosis often leads to devastating outcomes. This blog explores recent developments and collaborations with a shared mission — to transform the landscape of pancreatic cancer detection and early screening methods, offering new hope for improved survival rates.

Advancements in Liquid Biopsy and Molecular Testing

Recent collaborations have introduced innovative approaches to early detection, utilizing liquid biopsy techniques and molecular testing. These technologies aim to detect specific biomarkers associated with pancreatic cancer through non-invasive means, such as blood tests.

Investigating biomarkers is one strategy for the early detection of pancreatic cancer. Researchers are looking for biomarkers that would help distinguish a person with undiagnosed pancreatic cancer from someone without the disease. People with a disease, compared to healthy people, sometimes have unusual levels of certain biomarkers.

Liquid biopsies, a growing field, involve the analysis of genetic material, such as circulating tumor DNA (ctDNA), circulating tumor cells (CTCs) or exosomes found in bodily fluids. These non-invasive tests hold immense potential for routine monitoring, offering a convenient and accessible way to identify cancer-related changes at an early stage.

The collaboration between the PRECEDE Consortium and industry partners signifies a dedicated effort to accelerate the detection of pancreatic cancer at stages I or II, where treatment options are more viable. Driven by the goal to increase the survival rate from 12.5% to 50%, this partnership holds promise in significantly improving surveillance and transforming our ability to detect pancreatic cancer at its earliest and most treatable stages.

DNA-Based Blood Tests

These DNA-based blood tests are designed to assess epigenomic and genomic alterations associated with cancer and are emerging as powerful tools in the early detection arsenal. By analyzing specific DNA signals and using machine learning algorithms, these tests can identify abnormal patterns indicative of early-stage pancreatic cancer or high-grade dysplasia. These tools will help us progress to our goal of detecting cancer earlier, especially in high-risk individuals, when life-saving treatment is more likely to succeed.

PRECEDE’s collaboration efforts, supported by TrovaNow, are an integral part of the consortium’s observational longitudinal prospective cohort study, which has already enrolled over 5,600 participants globally. The goal is to use the test as a surveillance tool alongside standard imaging, to further validate and expand its use in various high-risk groups.

Artificial Intelligence in Imaging

The integration of artificial intelligence (AI) in imaging processes is enhancing the accuracy and efficiency of cancer detection, leading the way for more better and reliable diagnostic methods. AI algorithms can analyze medical images, such as CT scans or MRIs very quickly and accurately, aiding clinicians in identifying potential abnormalities that may be indicative of early-stage cancer.

Collaborative Approach

The unique model of collaboration and data sharing within the PRECEDE Consortium is a unique approach that demonstrates how the medical community can tackle complex challenges like pancreatic cancer by working together. With over 40 academic medical centers and more than 5,600 high-risk study participants involved, the consortium exemplifies the power of collective intelligence in advancing cancer research.

Potential Impact on Pancreatic Cancer Survival Rates

All the work being done by the PRECEDE Consortium in the area of early detection share a common mission — to increase the survival rate for pancreatic cancer from 12% to 50% within the next decade. The significance of these partnerships lies not only in their potential to revolutionize early detection but also in their commitment to achieving this ambitious goal through collaborative efforts.

The integration of these technologies into early cancer detection efforts carries the potential to significantly impact pancreatic cancer survival rates. By identifying the disease at its earliest, most treatable stages, patients may have access to a broader of treatment options, ultimately improving their chances of survival.

Advantages and Future Prospects

The advantages of these emerging technologies are evident: non-invasiveness, accessibility and the potential for earlier diagnosis. As these methods continue to evolve, there is hope that they will become instrumental in transforming the prognosis of pancreatic cancer and potentially other forms of cancer as well.

The recent collaborations with the PRECEDE Consortium represent significant progress in the quest for early pancreatic cancer detection. As these technologies improve, there is hope for a future where pancreatic cancer can be diagnosed and treated at its earliest, most manageable stages, significantly improving the survival rates for those at risk.

The developments of liquid biopsy techniques, DNA-based blood tests and AI in imaging showcases a multi-faceted approach that holds the promise of revolutionizing not just pancreatic cancer but also for other types of cancer.

Stay informed about the latest advancements in early cancer detection, support ongoing research initiatives or organizations working tirelessly to improve cancer survival rates and advocate for increased awareness. Together, we can contribute to a future where early detection becomes a crucial part of the fight against cancer, bringing about improved outcomes for increased chances of survival for patients worldwide.

Learn How You Can Get Involved And Donate Today

Not going down without a fight, especially when it comes to pancreatic cancer! Every challenge we face is an opportunity to grow stronger and more resilient in the battle against this relentless disease.

TrovaNOW proceeds go towards collaborative research to detect pancreatic cancers earlier, saving thousands of lives from the world’s deadliest cancer. Our goal is to raise $1,000,000 to help fund the Pancreatic Cancer Early Detection (PRECEDE) Consortium – an innovation hub that welcomes collaboration, while also disseminating new protocols and scientific discoveries.

To be part of this impactful movement, visit www.trovanow.com. Discover how you can contribute, get involved and make a positive difference. Your support today can contribute to a future where pancreatic cancer is detected early, treated effectively and lives are saved. Join us in the fight against pancreatic cancer — together, we can make a lasting impact.

Knowing When To Ask For Help

There’s strength in recognizing when you need additional support. If you’re feeling consistently overwhelmed, anxious, or depressed, it may be time to speak with a healthcare professional. Warning signs can include ongoing sleep trouble, loss of appetite, or emotional numbness.

Mental health care is an important part of cancer recovery. There are therapists, social workers, and cancer-specific counselors trained to support your unique needs. Don’t hesitate to seek them out.

Your medical team can help adjust medications or recommend physical therapy if your symptoms are impacting your daily life. Being honest about your struggles allows your care providers to offer better, more personalized support.

The path to recovery from pancreatic cancer is rarely straightforward. It’s a mix of triumphs and setbacks, strength and vulnerability. But through each high and low, healing is happening. Be gentle with yourself. Allow space for rest, reflection, and growth.

You don’t have to go through this journey alone. With the right support, emotional, physical, and practical, you can move forward, one step at a time. And remember, every day you show up for yourself is a victory.

At TrovaNOW, we’re focused on finding a cure for pancreatic cancer. Every test and discovery brings us closer to better treatments and saving lives. Join us and learn more at TrovaNOW.

PRECEDE Foundation Inaugural Gala

Join us for a night at the Tribeca Rooftop 360 on October 28th at 3:00pm PDT to honor the following awards:

Nobility in Science Award

Raymond C. Wadlow, MD

Catalyst for Change Award

Ambry Genetics Corporation

Legacy Awards

Jeffrey Johnson, Esq.

Jonathan Morris, Esq.

PRECEDE Leadership and Compassionate Care Award

Jessica Everett, MS, CGC

Co-Chairs

Scott Berger | Michael Gershenson | Tracy Chen

Honorary Chairs

Diane Simeone, MD | Jamie Brickell

Get tickets here.

A Long and Steadfast Battle Against a Terrible Cancer

Raymond Wadlow lost his mom, Emily Couric, to pancreatic cancer in 2001. Today he’s an oncologist pushing for early detection.

Why Building Muscle Matters (Strength Training After Cancer Treatment)

Cancer treatment is an incredibly challenging journey, often leaving survivors physically and emotionally drained. While survival is the primary goal, the road to recovery requires more than just healing from the illness itself, it requires rebuilding strength and endurance. One of the most effective ways to regain strength and improve quality of life after treatment is through strength training.

In this blog, we’ll explore why building muscle matters after cancer treatment, how strength training supports recovery, and why it’s important to include physical activity in a full recovery plan.

The Importance of Muscle Health in Cancer Recovery

During cancer treatment, particularly chemotherapy and radiation, the body goes through a variety of changes, including significant muscle loss. This can lead to fatigue, weakness, and a decrease in overall functional capacity. Survivors may also experience joint pain, decreased bone density, and difficulty with mobility. When muscles are weakened, it becomes more difficult to perform everyday tasks, affecting the ability to return to normal life.

Muscle health is crucial for maintaining daily functioning, increasing stamina, and improving the body’s ability to heal. Building muscle after cancer treatment can help counteract the physical decline caused by treatments, reduce fatigue, and increase energy levels. Strong muscles are also important for stability, balance, and preventing falls or injuries, which can be especially crucial as the body regains strength.

Benefits of Strength Training After Cancer Treatment

Physical Benefits

Strength training is an excellent way to rebuild muscle mass lost during cancer treatment. By focusing on resistance exercises that challenge the muscles, you can restore strength and regain physical independence. Whether through bodyweight exercises, free weights, or resistance bands, strength training helps increase muscle mass, boost stamina, and promote flexibility.

It also improves bone density, which is particularly important for cancer survivors who may be at risk of osteoporosis due to treatments like chemotherapy and hormone therapy. As you build muscle, you reduce the risk of bone fractures and improve posture and stability.

Mental and Emotional Benefits

Physical activity, especially strength training, has significant mental health benefits. Exercise releases endorphins, which are natural mood boosters that help reduce anxiety and depression. Cancer survivors often experience feelings of helplessness and loss of control. Strength training helps you regain control over your body, build confidence, and feel accomplished.

Strength training offers mental benefits like improved mood and focus. Research shows that regular exercise can also help manage the cognitive effects of cancer treatment, such as “chemo brain,” which can cause memory issues, difficulty concentrating, and brain fog. Strength training can improve cognitive function, helping survivors feel more mentally sharp and focused.

Long-Term Health Benefits

Strength training can help prevent long-term complications of cancer treatment. Conditions such as sarcopenia (muscle wasting) and metabolic syndrome, which involves high blood pressure, high blood sugar, and abnormal cholesterol levels, are common among cancer survivors. Building muscle through strength training can help manage these conditions and reduce the risk of chronic diseases.

Muscle health supports overall immune function and metabolism. Strong muscles help regulate blood sugar levels, enhance circulation, and improve the body’s ability to absorb nutrients, critical for recovery and long-term health.

The Science Behind Strength Training for Cancer Survivors

Strength training works by creating small tears in muscle fibers, which, when repaired, become stronger over time. After cancer treatment, the body may be in a weakened state, but through consistent resistance training, it begins to rebuild muscle tissue. This process is essential for improving muscle mass and overall body strength.

Strength training promotes hormone regulation, which can be disrupted by cancer treatments. Chemotherapy and hormone therapy often interfere with estrogen and testosterone levels. Regular strength training helps balance these hormones, which can improve mood, energy levels, and general well-being.

Studies have shown that strength training can help cancer survivors reduce fatigue, improve cardiovascular health, and maintain a healthy weight. This holistic approach is vital to fully recovering from the effects of cancer treatment and returning to a normal, active lifestyle.

Key Considerations When Starting Strength Training Post-Treatment

Starting strength training after cancer treatment should be approached with care. The body may be more sensitive and vulnerable in the recovery phase, so it’s essential to consult with a healthcare provider or physical therapist before beginning an exercise program.

Start Slow and Progress Gradually: Don’t jump into intense workouts right away. Begin with low-impact exercises that focus on mobility, flexibility, and core strength. Gradually increase the intensity and duration of your workouts as your body adapts. Listen to your body, rest when needed, and avoid pushing too hard.
Focus on Recovery and Balance: Incorporating rest days into your routine is just as important as training days. Overtraining can lead to injury or burnout, so make sure you balance strength training with adequate recovery. This includes prioritizing sleep, nutrition, and hydration as part of your overall fitness plan.
Adapt Exercises to Your Body’s Needs: Cancer treatment can result in lingering side effects like joint pain, fatigue, and reduced range of motion. Modify exercises to accommodate these challenges. Resistance bands and light weights can be excellent starting points for those who need to ease into strength training.

Effective Strength Training Exercises for Cancer Survivors

Cancer survivors can begin their strength training journey with simple, low-impact exercises that target the major muscle groups. Here are some effective exercises to get started:

Bodyweight Squats: Squats are a great full-body exercise that targets the legs, glutes, and core. Start by performing shallow squats and gradually increase the depth as you build strength.
Wall Push-ups: Wall push-ups are an excellent way to build upper body strength without straining the shoulders or wrists. As you gain strength, progress to standard push-ups or modified knee push-ups.
Resistance Band Exercises: Resistance bands are perfect for adding gentle resistance to exercises like bicep curls, shoulder presses, and leg extensions. They provide controlled resistance that’s easier on the joints.
Dumbbell Exercises: Once you’ve built up some strength, you can incorporate light dumbbells for exercises like lunges, chest presses, and rows to continue building muscle.
Core Workouts: Strengthening your core is essential for improving balance and stability. Exercises like planks, bird dogs, and leg raises are great for building a solid foundation of strength.

Building a Strength Training Routine

Creating a strength training routine that fits your needs is essential for long-term success. Here are some tips for creating a sustainable workout plan:

Frequency: Aim for two to three strength training sessions per week, spaced out to allow for adequate recovery.
Duration: Start with 20-30 minute sessions and gradually increase the time as your body becomes more accustomed to the routine.
Progression: Increase the resistance, repetitions, or sets as you build strength. A good rule of thumb is to challenge your muscles without overexerting yourself.
Consistency: Make strength training a regular part of your life, but be patient with the process. Progress may be slow, but every step forward is a victory.

Building muscle after cancer treatment is a powerful tool in the recovery process. Strength training not only helps rebuild muscle mass and physical strength, but it also provides emotional and mental benefits that can enhance overall well-being. By embracing a thoughtful, gradual approach to strength training, cancer survivors can regain control of their bodies, improve their health, and achieve a higher quality of life. Remember, consistency is key, strength comes over time.

In 2025, TrovaNow is expanding its impact—with a 40% increase in fundraising goals and more research sites dedicated to supporting cancer recovery. Visit www.trovanow.com to see how you can get involved and donate today.